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Ренат Рашитович Ахмеров

Доктор медицинских наук
разработчик системы Плазмолифтинг®

Effect of single injection of Platelet-Rich Plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial

Forogh B1, Mianehsaz E, Shoaee S, Ahadi T, Raissi GR, Sajadi S.



Evidence on the effect of Platelet-Rich Plasma (PRP) in treating osteoarthritis (OA) is insufficient. Therefore, the present study compares the effects of a one-time injection of PRP and corticosteroid (CS) as two types of treatment for the patients suffering from osteoarthritis.


In the present randomized double blind clinical trial, the participants who suffered from knee osteoarthritis (Grades II/III), were randomly divided into two groups: intra articular injection of PRP and CS. Knee injury and osteoarthritis outcome score (KOOS), the 20-meter-walk test, active and passive ranges of motions (ROM), flexion contracture, and pain intensity based on Visual Analog Scale (VAS) were assessed before, 2-months, and 6-months after interventions.


41 participants (48 knees) were involved in the research (66.7% women; average age of 61.1±7.0 years old). Compared to the group treated with corticosteroid, pain relief (df:6 ,35 ;F=11.0 ;p=0.007), symptom free (df:6 ,35 ;F=23.0 ;p<0.001), activities of daily living (ADL) (df:6 ,35 ;F=10.7 ;p=0.005) and quality of life (df:6 ,35 ;F=5.2 ;p=0.02) in the RPR group were significantly higher, but sporting ability was not different between the 2 groups (df:6 ,35 ;F=0.6 ;p=0.55). PRP prescription was significantly more helpful for relieving patients' pain (VAS) compared to corticosteroids (df:6,35;F=32.0 ;p,0.001).It's also notable that using PRP was more helpful in improving the 20-meter-walk test than corticosteroid treatment (df:6 ,35 ;F=7.4 ;p=0.04) but none of the treatments had any impact on active flexion ROM ?passive flexion ROM and flexion contracture (p>0.05).


Our study demonstrated that one shot of PRP injection, decreased joint pain more and longer-term, alleviated the symptoms, and enhanced the activity of daily living and quality of life in short-term duration in comparison with CS.

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